Hair loss and hair graying have been long-believed to be a consequence of geneti…
Hair loss and hair graying have been long-believed to be a consequence of genetics and aging. Despite advances in our understanding of environmental factors (diet, lifestyle, etc.) in hair loss, the current model still stands.
Vitamin D receptors are highly expressed in both the hair follicle and the skin that incubates it. This suggests it plays a role in the health of both the follicle and the skin.
At a molecular level, vitamin D activates genes that are important for maintaining hair follicle health:
✔️ Nephronectin: a protein around cells that maintains the stem cells needed for hair follicle regeneration after shedding and supports the structure required for a healthy hair follicle
✔️ Fibronectin: a protein around cells that prevents inflammation and supports the structure of the hair follicle. Removal of the fibronectin receptor leads to inflammation around the mouse hair follicle that contributes to hair loss.
Vitamin D3 deficiency and abnormalities in vitamin D metabolism have been associated with various forms of hair loss.
Vitamin D also activates genes responsible for hair pigmentation:
✔️ Tyrosine hydroxylase: an enzyme that is a critical step in the formation of melanin, the pigment that colors hair.
Preliminary studies corroborate these findings, demonstrating that premature graying is associated with vitamin D3 deficiency.
Boosting Vitamin D:
✔️ Safe sun exposure without sunscreen
✔️ Eat magnesium-rich foods to support Vitamin D absorption
✔️ Ensure balance in the body by consuming the other three fat-soluble vitamins: A, E, and K.